Mercyhurst University, formerly Mercyhurst College, is a private Roman Catholic university in Erie, Pennsylvania. On September 20, 1926, Mercyhurst College opened its doors just a few blocks away from the city's southern boundary. It was founded by the Sisters of Mercy of the Diocese of Erie, who were led by Mother M. Borgia Egan, who became the first president of Mercyhurst College. The college received its charter on October 5, 1928.

In 1963, the college prep department separated to form Mercyhurst Preparatory School, which is located behind the university. On February 3, 1969, the board of trustees voted to make Mercyhurst a coed college. From its foundation in 1926 until 1972, members of the Sisters of Mercy had been presidents of the college. After 1972, lay presidents led the college. On March 27, 1991, Mercyhurst purchased the 100-year-old Redemptorist Seminary in North East and turned it into a branch campus, offering associate degrees and one-year certificates